Observations on Leukemia in Wistar and Wistar Furth Rats

Observations on leukemia in Wistar Furth rats.

Observations on Leukemia in Wistar and Wistar Furth Rats.

By WILLIAM C. MOLONEY, ANTONIO E. BOSCHETFI AND GERALDINE Down T HIS INVESTIGATION is concerned with studies on leukemia occurring in a series of noninbred Wistar and inbred Wistar Furth ( W/Fu ) rats treated with whole body x-ray and oral administration of 3 methylcholanthrene ( 3MCA ) . The animals were followed by serial leukocyte counts and examination of peripheral blood smears. At the tim...

Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats.

One of the most consistent results in the epidemiology of human breast cancer is the inverse relationship of risk and early full-term parity. The goal of this study was to investigate the molecular mechanisms through which early full-term pregnancy protects the breast from cancer development. We used Wistar-Furth (WF) rats as our experimental system and mimicked pregnancy using estrogen and pro...

The Wistar Furth rat: an animal model of hereditary macrothrombocytopenia.

The mechanisms that determine and regulate platelet size are unknown. By phase microscopy, we observed that Wistar Furth (WF) rats had macrothrombocytopenia. In this study, we have characterized and compared platelets and megakaryocytes of WF rats with those of Wistar, Long-Evans hooded (LE), and Sprague-Dawley rats. In addition, we have examined the mode of inheritance of this WF rat platelet ...

Passive transfer of diabetes from BB/W to Wistar-Furth rats.

Autoimmune diabetes can be transferred to young, diabetes prone BB/W rats by injecting them intravenously with concanavalin A (Con A)-treated spleen cells from acute diabetic BB/W donors. This study describes the transfer of diabetes to the normal Wistar-Furth strain of rats using a similar procedure. For the successful transfer of diabetes it was necessary to immunosuppress recipient animals w...